The Damietta protein design engine allows mutation as well as repacking and combinatorial sampling for protein design. Download here. More information here.
The Damietta protein design server is a user-friendly access to the design engine as well as other protein design tools. Try it out here.
HECTOR method is a geometric search scheme that can identified highly complementary interfaces and perform steric docking with efficiency that enables ultra-high throughput docking. The resulting interfaces provide structural templates for the sequence design of tight binders. HECTOR code is available here.